Macrophage Differentiation
Introduction
Macrophages are white blood cells that are produced in the bone marrow and circulate in the blood as monocytes. In response to various cytokines, they differentiate into macrophages in the peripheral tissues. They perform important functions in tissue homeostasis and the immune response and have been implicated in a range of diseases including atherosclerosis, autoimmune disease and brain injury.
For your research AbD Serotec offers an extensive range of human, mouse and rat reagents for differentiating macrophages. The range includes a wide choice of clones, formats and conjugates – including Alexa Fluor ® 405, 488, 647 and 700 fluorochromes, plus our new tandem conjugates.
With such a wide choice of antibodies and excellent product support it is no wonder we are your first choice for antibodies!
Featured Products
MCA497 - The only pan-specific macrophage marker that recognizes microglia…
The F4/80 antigen has been well characterized and referenced as an excellent marker for almost all mature mouse macrophages and blood monocytes. Clone C1:A3-1 (MCA497) is the original monoclonal against the F4/80 antigen, with the added benefit of recognizing microglia in the brain for neurological studies. Today, AbD Serotec is the primary distributor of this antibody offering new RPE-Alexa 647 and RPE-Alexa 750 tandem conjugates for flow cytometry.
ED clone range
AbD Serotec is the primary source of the ED clones, which are a comprehensive range of reagents for the study of rat macrophages. These antibodies have a wide range of applications and can be used in immunohistochemistry. Of particular note is MCA341 - anti-CD68 (ED1) - which is the most reliable rat macrophage marker.
Literature Download
Antibodies to Rodent Dendritic Cells & Macrophages
Please click here
for a poster detailing our key rat and mouse antibodies for detecting dendritic cells (DCs) and macrophages.
