Neurology Antibody Range
Neuroscience research is a versatile subject which incorporates many different scientific disciplines, including: cell biology, endocrinology, developmental biology, and behavioral studies. At AbD Serotec we are dedicated to providing high quality neuroscience reagents, with a number of key specificities in areas such as:
- Development & Repair
- Neural Stem Cells
- Neuronal and Glial Markers
- Neurotransmitters, Receptors, and Transporters
- Neuroendocrinology
- Neurodegeneration and Neurological Disease
Development and Repair
Development of the nervous system occurs via cellular and molecular mechanisms that arise during embryogenesis. Neurogenesis encompasses the differentiation of neural stem cells (NSC) first into neurons, and later into axonal outgrowth via growth cones that respond to guidance cues. Our key growth cone marker (MCA1712, clone 2G13) is ideal for studying axonal growth. The target recognized by this antibody, 2G13P, is localized to growth cones, particularly filopodia and lamellipodies in developing rat CNS and embryonic neurons in culture. Studies suggest that the protein detected interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility. Additional key axonal growth markers are also available.
Lessons from neural development are important as well when studying repair mechanisms in the central nervous system following brain damage, since it is often unable to repair itself and requires medical intervention.
Neural Stem Cells
Neural Stem Cells (NSC) are an area of intense interest in neuroscience research and clinical studies. This is due to their potential use in repairing brain injury following a stroke. Neural stem cells are precursor cells with the unique ability to differentiate into various neuronal cell types, including neuroglia and dendrites. Manipulation of NSC lineages therefore has the potential to be of significant benefit in repairing neuronal damage. Multiple markers are available for detecting neural stem cells at different stages, and our range includes a number of key specificities such as: NCAM, Notch, Nestin, and NeuroD1
Neuronal and Glial Markers
Neurons are the backbone of the central and peripheral nervous systems. They originate from NSCs, and are electrically excitable cells which play a key role in detecting, processing, and transmitting information around the body and brain.
Glial cells (also known as neuroglia) support neurons in the central nervous system (CNS). They do not carry nerve impulses, but help modulate neurotransmission by providing insulation, nutrition, and support. Microglial cells, astrocytes, and oligodendrocytes are all types of glial cells. With the exception of microglia, glial cells are derived from ectodermal tissue in the developing embryo, originating from neural stem cells (NSCs). Microglia originate from hematopoietic stem cells instead, and act by migrating around the nervous system in search of neuronal damage.
Our range of glial and neuronal markers is extensive, including the very popular antibody against rat microglia, F4/80 (MCA497, clone C1:A3-1), which is produced by AbD Serotec in the greatest range of conjugated formats commercially available.
Neurotransmitters, Receptors, and Transporters
Neurotransmission is simply the propagation of a nerve impulse. Research in this area focuses on the production and transport of neurotransmitters in the synapse. After neurotransmitters have been released into the synaptic cleft, they are received by receptors in the postsynaptic neuron in order to relay a signal. This important research area is critical to an understanding of neurological disorders such as epilepsy and addiction. Download our neurotransmitter pathways poster, a fantastic illustrative overview of the Glutaminergic, GABAergic, and Dopaminergic synapses and their relationship with neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia.
Neuroendocrinology
Neuroendocrine cells function by releasing hormones in response to signals from the nervous system. The hypothalamus is a neuroendocrine gland located in the brain which controls a large proportion of the hormones in our body via the pituitary gland, and also regulates our sleep, reproductive, and stress responses. Since so many body systems are affected by neuroendocrinology, a large range of research disciplines are also involved. AbD Serotec offers over 300 endocrinology antibodies, including key neuroendocrine hormones and receptors.
Neurodegeneration and Neurological Disease
Neurodegeneration is basically the progressive loss of neurons via apoptosis, structural abnormalities, or a general failure to function. There are a number of high profile diseases which are considered to be neurodegenerative including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, as well as Amyotrophic Lateral Sclerosis (ALS). Due to the increasing prevalence of these disorders, this is one of the biggest and most rapidly growing areas of neurologic research. At AbD Serotec we have made neurodegenerative diseases a key focus area, with reagents that include a panel of antibodies to the huntingtin protein and antibodies to amyloid beta 1-42 for staining amyloid plaques in Alzheimer’s disease brains.
DownloadEssential Antibody Tools for Studying Parkinson’s Disease |
DownloadKey Antibodies for Studying Alzheimer’s Disease |
