Macrophage and Dendritic Cell Antibodies

Macrophages and Dendritic Cells

Macrophage Antibodies

Macrophages are long lived cells that are central to the immune system and present throughout the body. They are found in connective tissue, around the basement membranes of small blood vessels, and in lymphoid and non-lymphoid organs, such as: lung (alveolar macrophages), liver (Kupffer cells), and kidney (mesangial).

Upon recognition of microbial targets, there are changes in the macrophage cell surface. This results in the uptake of the pathogen, activation of signaling pathways, altered gene expression, and the induction of acquired immunity.

Dendritic Cell Antibodies

Dendritic cells (DC) are antigen presenting cells that are critical for the induction of the primary immune response. Upon entering a particular tissue, DC precursors become immature DC, which capture and process antigen. Next, they migrate to the spleen and lymph nodes, where they develop into mature DC expressing the MHC-peptide complex for presentation to antigen specific lymphocytes.

There are four types of dendritic cells:

Follicular - which promote the differentiation of B cells.
Myeloid - which stimulate Th1 cells.
Lymphoid - which activate Th2 cells.
Plasmacytoid - which link the innate and adaptive immune responses upon maturation.

Key Macrophage and Dendritic Cell Markers

AbD Serotec manufactures a comprehensive range of antibodies for the study of macrophages and dendritic cells. As the originating source of the renowned F4/80 clone CI:A3-1(MCA497), we offer over 30 different labels and formats. All of our antibodies are guaranteed for use in a wide range of applications.

In addition, we produce the popular anti-CD68 clone ED1 (MCA341). This marker is expressed predominantly on the lysosomal membrane by the majority of tissue macrophages.

F4/80	ED Clones
CD36	CD205
CD83	CD206
CD200	Human Macrophages

Download Macrophage Flyer