Pattern Recognition Receptor Antibodies
Pattern recognition receptors play a key role in the innate immune response by recognizing pathogen associated molecular patterns (PAMPS) derived from a diverse collection of microbial pathogens, which include: bacteria, viruses, parasites, fungi, and protozoa. They fall into three broad functional groups:
- Cell-based PRRs that active pro-inflammatory signaling pathways – these result in the induction of genes to produce anti-microbial peptides, lysozymes, inflammatory cytokines, and chemokines. They also increase the expression of molecules involved in activation of adaptive immunity
- Cell-based PRRs that stimulate phagocytic responses in macrophages, neutrophils, and dendritic cells - these bind microbial PAMPs and mediate the process of phagocytosis or endocytosis. In macrophages and dendritic cells internalized microbes are then processed into peptides for presentation to T cells by MHC molecules.
- Fluid based PRRs that form part of the humoral arm of the innate immune system - these are recognized by receptors expressed on cells of the innate immune system. Members include collectins, ficolins, and pentraxins.
Key Pattern Recognition Receptor Markers
AbD Serotec offers a wide variety of antibodies against all three groups of PRRs. Intracellacullar PRR targets include the cytoplasmic helicase protein RIG-I, which causes recruitment of VISA, downstream activation of TBK1 and IKK-i kinases, phosphorylation of IRF3 and IRF7, and the production of type-1 interferons.
Cell-based phagocytic PRR targets include: CD204 (MSR1), Scavenger receptor type A, CD206, and MARCO. Examples of fluid based PRRs include PTX3, C-Reactive Proteins, and the Mannan Binding Protein.
Dectin -1 |
TREM-1 |
Inflammasome |
CD209 |
Download Toll-like Receptor Poster |
Download PRR Flyer |
