Aurora A Kinase Antibodies

  • Useful in a wide range of applications
  • Suitable for formalin-fixed paraffin-embedded tissue sections
  • Choice of formats
  • Performance guarantee

Role of Aurora A kinase
Our versatile range of Aurora A kinase antibodies

Specificity Target Species Host Species Clone Format Pack Size Applications Product Code
AURORA-A KINASE Human Rabbit   Purified 0.05 mg C, IP AHP873
AURORA-A KINASE N/A   Blocking peptide Purified IP, WB 50 ug BLP003

 
AURORA-A KINASE Human Mouse 35C1 Purified 0.1 mg IF, IP, WB MCA2249
AURORA-A KINASE Human Mouse 35C1 Biotin 0.1 mg IF, WB MCA2249B
AURORA-B KINASE Human Rabbit   Purified 0.05mg E, WB AHP1261
KINESIN FAMILY MEMBER 5C Human Mouse 1203 Purified 0.1 mg E, WB HCA010
TACC3 Human Mouse 6C4 Az.Fr 0.1mg P*, WB MCA3705Z

Role of Aurora A Kinase

paffCell cycle progression through mitosis and meiosis involves regulation by serine/threonine kinases from the Aurora family (1). A key member of the Aurora family is Aurora A Kinase (Aurora 2, murine serine/threonine Kinase 6 (STK6), human serine/threonine Kinase 15 (STK15)).

During interphase, Aurora A Kinase localises to the centrosome, which organizes microtubule assembly into a mitotic spindle. Aurora A Kinase regulates mitotic spindle assembly and stabilization through the recruitment of different proteins including Kinesin 5 and TACC 3 (2.)

Aurora A Kinase expression is regulated by the tumor suppressor protein p53, which is found at the centrosome during mitosis. p53 binds and inhibits Aurora A Kinase activity (3). Choose from our selection of quality p53 Antibodies.

Aurora A Kinase also acts as an oncogene as it has been shown to transform cells in vitro (4). The role of Aurora A Kinase in cancer is thought to be due to its dysregulation. This leads to cells unable to complete mitosis, resulting in aneuploid cells, which are a trait of many tumors (5). As Aurora A Kinase is over-expressed in many tumors, including breast, colon, leukemia, ovarian and prostate (1), it is now a target for cancer therapy.

Current research in the pharmaceutical industry includes the development of Aurora A Kinase inhibitors as novel cancer treatments, some of which are already in clinical trials (6),(7). Our cell biology range has a selection of quality products dedicated to Oncoprotein and Tumour Suppressor Protein Research.

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Our versatile range of Aurora A Kinase antibodies…

Our Aurora A Kinase Antibodies are suitable for immunohistochemistry of frozen tissue sections, immunofluorescence, immunoprecipitation and Western blotting. MCA2249 (Clone 35C1) is available in a choice of purified and biotin formats and also cross-reacts with mouse.
 It specifically recognizes an epitope within the non-catalytic N-terminal domain of Aurora A Kinase and does not inhibit Aurora A Kinase activity (8). These quality antibodies are part of our extensive Cell Cycle Associated Reagents from the cell biology range. Visit the Cell Biology microsite for further details now.

References
  1. Fu J. et al. (2007). Mol. Cancer Res. 5: 1-10.
  2. LeRoy P.J. et al. (2007). Cancer Res. 67: 5362-70.
  3. Chen, S.S. et al. (2002). Embo J. 21: 4491–4499.
  4. Bischoff, J.R. et al. (1998). Embo J8. 17: 3052–3065.
  5. Hoar K. et al. (2007). Mol. Cell Biol. 27: 4513-25.
  6. Ikezoe T. et al. (2007). Mol. Cancer Ther. 6: 1851-7.
  7. Carvajal R.D. et al. (2006). Clin. Cancer Res. 12:6869-75.
  8. Cremet, J. Y. et al. (2003). Molecular and Cellular Biochemistry 243: 123 - 131