Datasheet: AHP1567

Description:	GOAT ANTI HUMAN CD318 (C-TERMINAL)
Specificity:	CD318 (C-TERMINAL)
Other names:	CDCP1
Applications:	E, WB
Format:	Purified
Product Type:	Polyclonal Antibody
Isotype:	Polyclonal IgG
Quantity:	0.1 mg
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Product Details

Applications

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information.

	Yes	No	Not Determined	Suggested Dilution
Flow Cytometry
Immunohistology - Frozen
Immunohistology - Paraffin
Immunohistology - Resin
ELISA				1/16000
Immunoprecipitation
Western Blotting				1.0 - 3.0ug/ml

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

	Target Species	Human

	Product Form	Purified IgG - liquid

	Antiserum Preparation	Antiserum to human CD318 (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

	Buffer Solution	Phosphate buffered saline pH7.3

	Preservative Stabilisers	0.02% Sodium Azide (NaN₃) 0.5% Bovine Serum Albumin

	Approx. Protein Concentrations	IgG concentration 0.5mg/ml

	Immunogen	Peptide sequence C-PLLNTQEPMEPAE corresponding to the C-Terminal region of CD318 (NP_073753.3).

External Database Links

UniProt:

CDCP1_HUMAN

Entrez Gene:

CDCP1

	Synonyms	TRASK

	Specificity	AHP1567 specifically recognises an epitope within the C-terminal (CT) region of isoform 1 of human CD318, otherwise known as CDCP1 (CUB domain-containing protein 1), a novel type I transmembrane protein expressed on the surface of haematopoietic stem cell subsets, epithelial cells and breast carcinoma, and up-regulated in metastatic lung and colorectal tumours. Studies have shown the expression of CD318 on CD34⁺CD133⁺ leukaemic blasts from patients with AML (acute myeloid leukaemia) and CML (chronic myeloid leukaemia), suggesting a role for CD318 as a novel leukaemic diagnostic marker.

	Western Blotting	AHP1567 detects a band of approximately 90kDa in human colon cell lysates.

	Storage	Store at +4^oC or at -20^oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

	Shelf Life	18 months from date of despatch.

	Health And Safety Information	(A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Our Antibody Ranges

Datasheet: AHP1567

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