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Datasheet: MCA1937
Description: MOUSE ANTI HUMAN CD112
Specificity: CD112
Other names: PRR/NECTIN 2
Applications: C, F, IP
Format: Purified
Product Type: Monoclonal Antibody
Clone: R2-525
Isotype: IgG1
Quantity: 0.2 mg
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MCA1937 staining of CHO nectin2 cells
MCA1937 staining of CHO nectin2 cells
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Product Details

Applications
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information.
 YesNoNot DeterminedSuggested Dilution
Flow Cytometry  1/50 - 1/100
Immunohistology - Frozen   
Immunohistology - Paraffin   
Immunohistology - Resin   
ELISA   
Immunoprecipitation   
Western Blotting   
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline pH7.4
Preservative Stabilisers
0.09%Sodium Azide
Approx. Protein Concentrations
Isotype concentration 1.0 mg/ml
External Database Links
Click for detail UniProt:
Q92692PVRL2_HUMANRelated reagents
Click for detail Entrez Gene:
5819PVRL2Related reagents
Click for detail GO:
GO:0005886plasma membraneRelated reagents
GO:0007156homophilic cell adhesionRelated reagents
GO:0015026coreceptor activityRelated reagents
GO:0042803protein homodimerization activityRelated reagents
Synonyms
HVEB, PRR2
Specificity
MCA1937 recognises CD112 Poliovirus Receptor Related 2 (PRR2), a new surface molecule, which has been reported to be homologous to the poliovirus receptor (CD155). Studies demonstrate that PRR2 expression is restricted to the myelo-monocytic and megakaryocytic lineages. PRR2 expression has also been detected on haematopoeitic progenitors expressing CD34.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Method sheets are available on request.
References
1. Lopez, M. et al. (1998) The Human Poliovirus Receptor Related 2 protein is a new Hematopoietic/Endothelial Homophilic Adhesion Molecule. Blood 92: 4602-4611.
2. Goyert, S.M. (1998) White cell differentiation antigens, Myeloid Antigens: section report. Leucocyte typing VI. Kishimoto, T. et al. eds (Garland Publishing Inc. New York) p. 956-957
Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Health And Safety Information
(A full Health and Safety assessment is available upon request) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Image

MCA1937 staining of CHO nectin2 cells

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Recommended Negative Controls

For research purposes only, unless otherwise specified in writing by AbD Serotec.

'M129875:090728'


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Printed on 31 Jul 2010