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Datasheet: MCA2155
Description: MOUSE ANTI HUMAN CD206
Specificity: CD206
Other names: MANNOSE RECEPTOR C TYPE 1
Applications: C, F, WB*
Format: Purified
Product Type: Monoclonal Antibody
Clone: 15-2
Isotype: IgG1
Quantity: 0.2 mg
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Product Details

Applications
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information.
 YesNoNot DeterminedSuggested Dilution
Flow Cytometry   
Immunohistology - Frozen   
Immunohistology - Paraffin   
Immunohistology - Resin   
ELISA   
Immunoprecipitation   
Western Blotting(1)   
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
(1)Clone 15-2 recognises a protein of approximately 175kDa under Non-reducing conditions.
Target Species
Human
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09%Sodium Azide
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Immunogen
Purified human mannose receptor
External Database Links
Click for detail UniProt:
P22897MRC1_HUMANRelated reagents
Click for detail Entrez Gene:
4360MRC1Related reagents
Click for detail GO:
GO:0004872receptor activityRelated reagents
GO:0005537mannose bindingRelated reagents
GO:0005887integral to plasma membraneRelated reagents
GO:0006898receptor-mediated endocytosisRelated reagents
Fusion Partners
Spleen cells from immunised Balb/c mice where fused with cells of the SP2/0 Ag.14 mouse myeloma cell line.
Specificity
MCA2155 recognises human mannose receptor, also known as CD206, which is a 175kd transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages and dendritic cells and can also be found in a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Method sheets are available on request
References
1. Barrett-Bergshoeff, M. et al. (1997) Monoclonal antibodies against the human mannose receptor that inhibit the binding of tissue-type plasminogen activator. Thromb Haemost. 77: 718-24.
2. Koning, N. et al. (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J Neuropathol Exp Neurol. 68: 159-67.
Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Health And Safety Information
(A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

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Recommended Negative Controls

For research purposes only, unless otherwise specified in writing by AbD Serotec.

'M137505:090825'


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Tel: +44 (0)1865 852700
Email: tech.uk@abdserotec.com
Web: www.abdserotec.com

Printed on 31 Jul 2010