Pattern Recognition Receptor Antibodies

Pattern Recognition ReceptorsPattern recognition receptors play a key role in the innate immune response by recognizing pathogen associated molecular patterns (PAMPs) derived from a diverse collection of microbial pathogens, which include: bacteria, viruses, parasites, fungi, and protozoa. They fall into three broad functional groups:

  • Cell-based PRRs that active pro-inflammatory signaling pathways – these result in the induction of genes to produce anti-microbial peptides, lysozymes, inflammatory cytokines, and chemokines. They also increase the expression of molecules involved in activation of adaptive immunity
  • Cell-based PRRs that stimulate phagocytic responses in macrophages, neutrophils, and dendritic cells - these bind microbial PAMPs and mediate the process of phagocytosis or endocytosis. In macrophages and dendritic cells internalized microbes are then processed into peptides for presentation to T cells by MHC molecules.
  • Fluid-based PRRs that form part of the humoral arm of the innate immune system - these are recognized by receptors expressed on cells of the innate immune system. Members include collectins, ficolins, and pentraxins.

Key Pattern Recognition Receptor Markers

AbD Serotec offers a wide variety of antibodies against all three groups of PRRs. Intracellacullar PRR targets include the cytoplasmic helicase protein RIG-I, which causes recruitment of VISA, downstream activation of TBK1 and IKK-i kinases, phosphorylation of IRF3 and IRF7, and the production of type-1 interferons.

Cell-based phagocytic PRR targets include: CD204 (MSR1), Scavenger receptor type A, CD206, and MARCO. Examples of fluid based PRRs include PTX3, C-Reactive Proteins, and the Mannan Binding Protein.

Dectin-1

TREM-1

Inflammasome

CD209