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CD29 antibody | 4B7R

Product Code Applications Pack Size List Price Your Price Qty
MCA1949
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F IF IP P * 0.2 mg loader
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loader
MCA1949T
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F IF IP P * 25 µg loader
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loader
MCA1949GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F IF IP P * 0.1 mg loader
List Price Your Price
loader

Mouse anti Human CD29 monoclonal antibody, clone 4B7R recognizes the human integrin beta 1 subunit, also known as CD29, a ~130 kDa (red) 115 kDa (non-red) single pass type I transmembrane glycoprotein expressed by most leucocytes and mesenchymal stem cells.

Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. Surface expression of CD29 on human natural killer cells can be reduced by pretreatment with the glutathione-S-transferase inhibitor diethyl maleate (Horvath-Arcidiacono et al. 2003)

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
MCA1949, MCA1949GA: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
MCA1949T: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
Occular melanoma cell line V+B2.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/25 1/50
Immunofluorescence
Immunohistology - Paraffin 1
Immunoprecipitation
Western Blotting
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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Description Goat anti Mouse IgG (Fc):FITC
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Description Mouse IgG1 Negative Control

References for CD29 antibody

  1. Marshall, J.F. et al. (1998) Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas.
    Br J Cancer. 77 (4): 522-9.
  2. Horvath-Arcidiacono, J.A. et al. (2003) Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions.
    Cell Immunol. 222: 35-44.
  3. Pillay, J. et al. (2010) Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia.
    J Leukoc Biol. 88: 211-20.
  4. Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.
    PLoS One. 6(3):e17454.
  5. Kim, B.S. et al. (2011) Effects of the dichloromethane fraction of dipsaci radix on the osteoblastic differentiation of human alveolar bone marrow-derived mesenchymal stem cells.
    Biosci Biotechnol Biochem. 75:13-9.
  6. Kato, H. et al. (2012) The primacy of β1 integrin activation in the metastatic cascade.
    PLoS One. 7 (10): e46576.
  7. Tan, D.W. et al. (2013) Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells.
    Development. 140 (7): 1433-44.
  8. Yi, T. et al. (2015) Manufacture of Clinical-Grade Human Clonal Mesenchymal Stem Cell Products from Single Colony Forming Unit-Derived Colonies Based on the Subfractionation Culturing Method.
    Tissue Eng Part C Methods. 21 (12): 1251-62.
  9. View The Latest Product References
  10. Chen, Y. et al. (2015) Effect of human umbilical cord mesenchymal stem cells transplantation on nerve fibers of a rat model of endometriosis.
    Int J Fertil Steril. 9 (1): 71-80.
  11. Gu, Q. et al. (2015) Ginkgo biloba extract promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in a pathway involving Wnt/β-catenin signaling.
    Pharmacol Res. 97: 70-8.
  12. Yang, J. et al. (2015) Cordycepin protected against the TNF-α-induced inhibition of osteogenic differentiation of human adipose-derived mesenchymal stem cells.
    Int J Immunopathol Pharmacol. 28 (3): 296-307.
  13. Sun, Y. et al. (2017) Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain.
    Pain Res Manag. 2017: 7346103.
  14. Lee, H.J. et al. (2017) ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells.
    Sci Rep. 7: 44486.
  15. Kim, S.H. et al. (2019) Forkhead box O1 (FOXO1) controls the migratory response of Toll-like receptor (TLR3)-stimulated human mesenchymal stromal cells.
    J Biol Chem. 294 (21): 8424-37.

Synonyms
Integrin Beta 1 Chain
RRID
AB_323203
UniProt
P05556
Entrez Gene
ITGB1

MCA1949

0611R 151775 162734

MCA1949T

160809 1806

MCA1949GA

150845 158665 166340

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