Accurate diagnosis of thyroid disorders is a common test for healthcare professionals. Thyroid disorders are classified under hyperthyroidism or hypothyroidism - in both cases the thyroid gland is not properly regulated, allowing it to become under-or over-active.
There are a number of suitable laboratory biomarkers for determining thyroid disorders; these include Tyroxine (T4), Thyroid Stimulating Hormone (TSH) and Triiodothyronine (T3).
T4 regulates metabolic processes in the body such as heart rate. T4 production is stimulated by TSH, and when T4 levels are high in the blood it reduces TSH levels by negative feedback. In hyperthyroidism levels of T4 are abnormally high and TSH levels are low, resulting in the thyroid gland being over stimulated. The reverse occurs in hypothyroidism, where levels of T4 are low and TSH levels will therefore be high, causing under-stimulation. For this reason T4 and TSH are regularly used simultaneously by healthcare professionals to detect an under or over-active thyroid.
T3 is also important in controlling metabolic processes and is more active in doing so than T4. The measurement of free T3 levels is generally carried out to determine hyperthyroidism, and the extent of this disorder.
Our range of antibodies to thyroid markers includes the following, all available in bulk for thyroid assays and controls:
|Mouse||TRIIODOTHYRONINE (T3)||Purified||3T50 (BGN/09/1250)||9160-0920|