Nearly one in seven couples experience trouble conceiving naturally, and must rely upon experts and specialty clinics to address the underlying causes of infertility. As a result diagnostic evaluations are untaken which often include preliminary and ongoing analysis of serum steroid hormone levels.
AbD Serotec offers an extensive range of quality antibodies to key steroid hormones which can be used in diagnostic evaluations as fertility markers. All antibodies are manufactured to ISO 9001:2008 and ISO 13485:2003 standards, and are guaranteed to perform to specification. Our global OEM Team can assist you in identifying the clones best suited to your diagnostic applications.
Testosterone is produced in the testes, promoting the development and maintenance of male secondary sex characteristics. It impacts both male and female fertility. In males, low testosterone levels can cause the cessation of sperm production, while increased testosterone levels may indicate testicular or adrenal tumors. High testosterone levels in women can cause irregular cycles or secondary amenorrhea, and may indicate PCOS (Polycystic Ovarian Syndrome), as well as ovarian or adrenal gland tumors. Our monoclonal antibody to testosterone (8680-1756, clone 4E1G2) has been demonstrated to show low levels of cross-reactivity to other closely related steroids. Since it demonstrates an affinity of 2.3 x 10?10 l/mole and a sensitivity of 26 pmoles/l, this clone is the perfect choice for diagnostic kits.
Estradiol is the primary estrogen produced by the ovaries and is an essential serum marker for assessing follicular development. As egg follicles grow and develop they secrete estradiol which stimulates the luteinizing hormone surge responsible for ovulation. High levels of estradiol may indicate problems with egg quality and quantity, and can suppress FSH or follicle stimulating hormone. Since lower levels of FSH or follicle stimulating hormones lead to lower pregnancy rates, poor ovulation, and a poor response to fertility-inducing drugs they may lead to lower success rates with IVF. In addition, extremely low levels of estradiol combined with high FSH or follicle stimulating hormone are indicative of ovarian failure.
Progesterone is produced in the ovaries during the second half of the menstrual cycle. Its role is to prepare the uterus for pregnancy. A progesterone test is typically carried out 7 days before an expected period and is used to check if ovulation has taken place.
With our commitment to excellence plus the technical resources needed to support your projects from start to finish, AbD Serotec is the first choice for high-quality, cost-effective outsourcing options for all your OEM needs.