Inflammation and Sepsis

High-quality Antibodies for Sensitive Inflammation and Sepsis Immunoassays

Laboratories are often asked to differentiate between inflammatory and non-inflammatory diseases. Inflammation is detected using tests such as the Erythrocyte Sedimentation Rate (ESR) or highly sensitive, quantitative immunoassays for acute phase proteins or inflammatory cytokines.

Antibodies to C-reactive Protein and Procalcitonin

C-reactive protein (CRP) is an unspecific marker of inflammation. CRP determination by immunoassay is a well-established laboratory test for the diagnosis and monitoring of inflammatory processes. New applications of CRP determination are as a risk factor for cardiovascular disease, and for risk evaluation of patients with angina pectoris.

As well as blood culture to identify infectious agents, and elevated C-reactive protein (CRP), elevated Procalcitonin (PCT) is recognized as a biomarker for sepsis. PCT is a precursor of the hormone calcitonin; in the thyroid gland, procalcitonin is cleaved into calcitonin, katacalcin and an N-terminal fragment. PCT is not released into the blood stream of healthy individuals. Since it was reported that there is an elevated level of PCT in patients with an infection of bacterial origin, PCT is considered to be the main marker of disorders accompanied by inflammation and sepsis.

AbD Serotec offers high-quality antibodies to C-reactive protein and procalcitonin, available in bulk for manufacture of these sensitive immunoassays.

Antibodies to C-reactive Protein and Procalcitonin