C-reactive protein (CRP) was discovered to an acute-phase protein and is an extremely sensitive marker for tissue damage and inflammation. CRP plays a part in complement binding and phagocytosis as well as having an important role in innate immunity. It belongs to the pentraxin family of calcium-dependent ligand-binding plasma proteins and is composed of five identical polypeptide subunits each containing 206 amino acid residues.
CRP was found to be a more accurate measure of inflammation than erythrocyte sedimentation rate and plasma viscosity. CRP rises above normal limits within 6 hours, and peaks at 48 hours. In acute inflammation, such as infection, there is up to a 50,000 fold increase. Apart from liver failure, there are few known factors that interfere with CRP production.
Various methods are available for CRP determination, such as ELISA, immunoturbidimetry, and latex agglutination tests. Monitoring C-reactive protein values can prove useful in determining disease progress or the effectiveness of treatments.
Infections: if CRP levels remain elevated after surgery then an infection may be present. Bacterial infections tend to give a higher CRP level than viral infections. CRP tests can also be used to see how well an anti-bacterial or anti-viral treatment is working.
Inflammatory disease: monitor diseases that cause inflammation, such as rheumatoid arthritis, lupus, or vasculitis and check if the anti-inflammatory medicine is working.
Malignancy: CRP levels go up quickly and then become normal quickly when responding to treatment.
There is also a strong positive association between base-line CRP concentration and BMI Weight loss can lower the CRP value. Therefore CRP production could also predict the development of type 2 diabetes.
New high-sensitivity CRP (hs-CRP) assays measure CRP but at a lower detection limit producing greater sensitivity than before. The hs-CRP test may be used to assess cardiovascular risk. Inflammation can damage the inner lining of the arteries and make having a heart attack more likely. However, the connection between high CRP levels and heart attack risk is not very well understood. Recent studies do show that CRP may also have a predictive application in cardiovascular disease (acute myocardial infarction, acute coronary syndromes, severe unstable angina, future atherothrombotic events, including stroke, and progression of peripheral arterial disease). Although it is not a specific prognostic marker, a level above 2.4 mg/l has been associated with a doubled risk of a coronary event.
AbD Serotec offers a number of reliable antibodies to C-reactive protein. All these antibodies are available in bulk quantities, and because they are supported by unrivaled technical support and our ISO quality system, they are ideal for immunodiagnostic kit development.