Application of HuCAL derived Antibodies
Epitope Mapping of Anti-Interleukin-13 Neutralizing Antibody CNTO607
Alexey Teplyakov, Galina Obmolova, Sheng-Jiun Wu, Jinquan Luo, James Kang, Karyn O’Neil, Gary L. Gilliland
Journal of Molecular Biology Volume 389, Issue 1, Pages 115-123
PMID: 19361524
Schistosoma mansoni TOR is a tetraspanning orphan receptor
on the parasite surface
C. LOCHMATTER, J. A. SCHIFFERLI and P. J. MARTIN
Department of Biomedicine, Immunonephrology, University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland
Abstract
Direct Detection of Disease Associated Prions in Brain and Lymphoid
Tissue Using Antibodies Recognizing the Extreme N Terminus of PrPc
Geoff Barnard, Lee Hopkins, Sowmiya Moorthie, David Seilly, Paul Tonks1
Reza Dabaghian, Jonathan Clewley, John Coward, Ian McConnell.
Department of Veterinary Medicine; University of Cambridge; Cambridge UK
Abstract
Human Monoclonal Antibodies Against Staphylococcal Enterotoxin B: Potential Therapeutics?
Eileen A. Larkin, Arman Bashirova, Martha L. Hale, Bradley G. Stiles, and Robert G. Ulrich Immunology Branch, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
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The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase
Andrei V. Chernov, Sergey A. Shiryaev, Alexander E. Aleshin, Boris I. Ratnikov, Jeffrey W. Smith, Robert C. Liddington, and Alex Y. Strongin
J. Biol. Chem. published 28 April 2008, 10.1074/jbc.M801719200
Abstract
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The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System
with a Novel Display Method for Efficient Selection of High-Affinity Antibodies.
Christine Rothe, Stefanie Urlinger, Corinna Löhning, Josef Prassler, Yvonne Stark, Ute Jäger, Bernd Hubner, Michael Bardroff, Ingrid Pradel, Melanie Boss, Renate Bittlingmaier, Tschimegma Bataa, Christian Frisch, Bodo Brocks, Annemarie Honegger and Margit Urban.
Abstract
Fab MOR03268 Triggers Absorption Shift of a Diagnostic Dye via Packaging in a Solvent-shielded Fab Dimer Interface.
Roman C. Hillig, Stefanie Urlinger, Jörg Fanghänel, Bodo Brocks, Cornelia Haenel, Yvonne Stark, Detlev Sülzle, Dmitri I. Svergun, Siegfried Baesler, Guido Malawski, Dieter Moosmayer, Andreas Menrad, Michael Schirner and Kai Licha.
Abstract
A Monoclonal Fab derived from a Human Non-Immune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse HIV-1 Strains.
Gustchina E, Louis JM, Lam SN, Bewley CA, and Clore GM. J. Virol. 2007 Sep 26; [Epub ahead of print]
Abstract
Recombinant Antibody Expression and Purification
Achim Knappik and Ralf Brundiers
AbD Serotec, a Division of MorphoSys AG,
Lena-Christ-Str. 48, D-82152 Martinsried, Germany
Abstract
Selection of vimentin-specific antibodies from the HuCAL® phage display library by subtractive panning on formalin-fixed,paraffin-embedded tissue.
Jarutat T, Nickels C, Frisch C, Stellmacher F, Hofig KP, Knappik A, Merz H.
| Biol. Chem. 2007 Jun; 388(6): 651–58
Abstract
Monovalent antibody scFv fragments selected to modulate T-cell activation by inhibition of CD86-CD28 interaction.
Kolly R, Thiel MA, Herrmann T, Pluckthun A. |
Protein Eng Des Sel. 2007 Feb 8 [Epub ahead of print]
Abstract
Direct selection of antibodies from complex libraries with the protein fragment complementation assay.
Koch H, Grafe N, Schiess R, Pluckthun A. |
J Mol Biol. 2006 Mar 24;357(2):427-41. Epub 2006 Jan 6
Abstract
Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model.
Boehncke WH, Ochsendorf FR, Noll S, Urban M, Popp A, Waldherr D, Haunschild J, Litzenburger T. |
Br J Dermatol. 2005 Oct;153(4):758-66
Abstract
Protein microarrays for antibody profiling: specificity and affinity determination on a chip.
Poetz O, Ostendorp R, Brocks B, Schwenk JM, Stoll D, Joos TO, Templin MF. |
Proteomics. 2005 Jun;5(9):2402-11
Abstract
Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats.
Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS, Ramamoorthi R, Roldan G, Ng P, Lum P, Hirth-Dietrich C, Tomkinson A, Brenner DA.
Abstract
An antibody library for stabilizing and crystallizing membrane proteins - selecting binders to the citrate carrier CitS.
Rothlisberger D, Pos KM, Pluckthun A. |
FEBS Lett. 2004 Apr 30;564(3):340-8
Abstract
Simultaneous metal chelate affinity purification and endotoxin clearance of recombinant antibody fragments.
Zimmerman T, Petit Frere C, Satzger M, Raba M, Weisbach M, Dohn K, Popp A, Donzeau M. |
J Immunol Methods. 2006 Jul 31;314(1-2):67-73. Epub 2006 Jun 22
Abstract
Characterization of high-affinity antibodies by electrochemiluminescence-based equilibrium titration.
Haenel C, Satzger M, Ducata DD, Ostendorp R, Brocks B. |
Anal Biochem. 2005 Apr 1;339(1):182-4.
Abstract
Characterization and HIV-1 Fusion Inhibitory Properties of Monoclonal Fabs Obtained From a Human Non-immune Phage Library Selected Against Diverse Epitopes of the Ectodomain of HIV-1 gp41.
Louis JM, Bewley CA, Gustchina E, Aniana A, Clore GM. |
J Mol Biol. 2005 Nov 11;353(5):945-51. Epub 2005 Sep 30.
Abstract
Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions
Vanhoutteghem, A., Djian, P. | Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12423-8, Epub 2006 Aug 4
Abstract
Isolation and comparative characterization of Ki-67 equivalent antibodies from the HuCAL phage display library
Jarutat, T., Frisch, C., Nickels, C., Merz, H., Knappik, A. | Biol Chem. 2006 Jul;387(7):995-1003
Abstract
Establishment of specific antibodies that recognize C106-oxidized DJ-1
Ooe, H., Iguchi-Ariga, S.M., Ariga, H. | Neuroscience letters, 2006 Aug 14, 404(1-2):166-9, Epub 2006, Jun 15
Abstract
Antibodies for proteomic research : Comparison of traditional immunization with recombinant antibody technology
Ohara, R., Knappik, A., Shimada, K., Frisch, C., Ylera, F., Koga, H. | Proteomics 6, 2638-2646 (2006)
Abstract
Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets
Sun, C., Kilburn, D., Lukashin A., Crowell, T., Gardner, H., Brundiers, * R., Diefenbach, B., Carulli, J.P. | Genomics 2003; Aug; 82(2): 130-142
Abstract
Human combinatorial Fab library yielding specific and functional antibodies against the human fibroblast growth factor receptor 3
Rauchenberger, R., Borges, E., Thomassen-Wolf, E., Rom, E., Adar, R., Yaniv, Y., Malka, M., Chumakov, I., Kotzer, S., Resnitzky, D., Knappik, A., Reiffert, S., Prassler, J., Jury, K. , Waldherr, D., Bauer, S., Kretzschmar, T., Yayon, A., Rothe, C. | J Biol Chem. 2003; Oct 3; 278(40): 38194-38205
Abstract
Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library
Cesaro-Tadic, S., Lagos, D., Honegger, A., Rickard, J. H., Partridge, L. J., Blackburn, G. M., and Plückthun, A. | Nat. Biotechnol. 21, 679-685, (2003)
Abstract
Biophysical properties of human antibody variable domains
Ewert, S., Huber, T., Honegger, A., and Plückthun, A. | J. Mol. Biol. 325, 531-553, (2003)
Abstract
Structure-based improvement of the biophysical properties of immunoglobulin v(h) domains with a generalizable approach
Ewert, S., Honegger, A., and Plückthun, A. | Biochemistry 42, 1517-1528, (2003)
Abstract
From EST to IHC: human antibody pipeline for target research
Frisch, C., Brocks, B., Ostendorp, R., Hoess, A., von Rüden, T., and Kretzschmar, T. | J. Immunol. Methods 275, 203-212, (2003)
Abstract
Microarray of recombinant antibodies using a streptavidin sensor surface self-assembled onto a gold layer
Pavlickova, P., Knappik, A., Kambhampati, D., Ortigao, F., Hug, H. | Biotechniques, 34(1), 124-130, (Jan. 2003)
Abstract
Antibody discovery: phage display
Kretzschmar, T., von Rüden, T. | Curr. Opin. Biotechnol. 13, 598-602, (2002)
Abstract
Self-immobilizing recombinant antibody fragments for immunoaffinity chromatography: generic, parallel, and scalable protein purification
Blank, K., Lindner, P., Diefenbach, B., Plückthun, A. | Protein Expr. Purif. 24, 313-322, (2002)
Abstract
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Nagy, Z.A., Hubner, B., Löhning, C., Rauchenberger, R., Reiffert, S., Thomassen-Wolf, E., Zahn, S. et al. | Nature Medicine, Volume 8, Nr. 8: 801-807 (August 2002)
Abstract
High-throughput generation and engineering of recombinant human antibodies
Krebs, B., Rauchenberger, R., Reiffert, S., Rothe, C., Tesar, M., Thomassen, E. | Journal of Immunological Methods, 254, 67-84, (2001)
Abstract
Bypassing hybridoma technology: HLA-C reactive human single-chain antibody fragments (scFv) derived from a synthetic phage display library (HuCal;) and their potential to discriminate HLA class I specificities
Marget, M., Sharma, B.B., Tesar, M., Kretzschmar, T., Jenisch, S., Westphal, E., Davarnia, P., Weiss, E., Ulbrecht, M., Kabelitz, D. , Krönke, M. | Tissue Antigens, 56, 1-9, (2000)
Abstract
Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display
Hanes, J., Schaffitzel, C., Knappik, A., Plückthun , A. | Nat Biotechnol., 18(12), 1287-92. (Dec. 2000)
Abstract
Titration of Infective and Noninfective Ff Filamentous Bacteriophages Using a Monoclonal Antibody against g3p
Frisch, C., Knappik, A., Choidas, M., Tesar, M. | BioTechniques 29:26-30 (July 2000)
Abstract
Fully Synthetic Human Combinatorial Antibody Libraries (HuCal) Based on Modular Consensus Frameworks and CDRs Randomized with Trinucleotides
Knappik, A., Ge, L., Honegger, A., Pack, P., Fischer, M., Wellnhofer, G., Hoess, A., Wölle, J., Plückthun, A., Virnekäs, B. | The Journal of Molecular Biology, 296, 57-86, Dec. 6 1999, (2000)
Abstract
New protein engineering approaches to multivalent and bispecific antibody fragments.
Plückthun, A., Pack, P. | Immunotechnology, 3(2), 83-105, (June 1997)
Abstract
Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen.
Rheinnecker, M., Hardt, C., Ilag, L.L., Kufer, P., Gruber, R., Hoess, A., Lupas, A., Rottenberger, C., Plückthun, A., Pack, P. | The Journal of Immunology, 157(7), 2989-2997, (Oct. 1, 1996)
Abstract
Engineered turns of a recombinant antibody improve its in vivo folding
Knappik, A., Plückthun , A. | Protein Eng., 8(1), 81-90, (Jan. 1995)
Abstract
Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis.
Virnekäs, B., Ge, L., Plückthun, A., Schneider ,K.C., Wellnhofer, G., Moroney, S.E. | Nucleic Acids Research, 22(25), 5600-5607, (Dec. 25 1994)
Abstract
Improved bivalent miniantibodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Eschericia coli.
Pack, P., Kujau, M., Schroeckh, V., Knupfer, U., Wenderoth, R., Riesenberg, D., Plückthun, A. | BIO/TECHNOLOGY, 11(11), 1271-1277, (Nov. 1993)
Abstract
