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Resources supporting the use of HuCAL® recombinant monoclonal antibodies


Designed just for you

Discover the technology behind Bio-Rad’s custom recombinant antibodies.

Watch our latest video to see inside Bio-Rad’s custom antibody facility. Learn from antibody experts how your requirements for specialized custom antibodies can become a reality through the use of HuCAL technology.


Features

How to improve your antibody drug development assays with anti-idiotypic antibodies​

How specialized antibody reagents address the challenges of CAR-T cell therapy development

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Drug development and bioanalysis

Webinars

Overcome the Challenges of PK Assay Development Using TrailBlazer Antibodies

Overcome the challenges of PK Assay development using TrailBlazer Antibodies
 

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Generation of SARS-CoV-2 antibodies in multiple formats within four weeks

Generation of SARS-CoV-2 antibodies in multiple formats within four weeks
 

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Recombinant antibodies with SpyTag technology

Recombinant antibodies with SpyTag technology

 

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Transform your bioanalytical assay development with TrailBlazer Antibodies

Transform your bioanalytical assay development with TrailBlazer Antibodies
 

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Five ways to control your critical antibody reagents and avoid bioanalytical assay failure

Five ways to control your critical antibody reagents and avoid bioanalytical assay failure

Watch Now

How to improve your antibody drug development assays with anti-idiotypic antibodies​

How to improve your antibody drug development assays with anti-idiotypic antibodies

Watch Now

Optimize your assays using recombinant antibodies selected for desired affinity

Optimize your assays using recombinant antibodies selected for desired affinity

Watch Now

The making of recombinant anti-idiotypic antibodies for high performance in bioanalytical assays

The making of recombinant anti-idiotypic antibodies for high performance in bioanalytical assays

Watch Now


Videos

Dr Christian Frisch explains how we generate anti-idiotypic antibodies for bioanalytical assay development using the HuCAL recombinant antibody technology; recorded at the EBF 8th Open Meeting.

Hear how Bio-Rad’s recombinant anti-idiotypic antibodies, made using HuCAL technology, fulfill the high quality standards demanded for use in assays to support the clinical evaluation of monoclonal antibody drugs; recorded at the EBF 9th Open Meeting.

Michael Schwenkert describes how high sensitivity PK assays can be developed using specialized drug-target complex specific antibodies, avoiding the ELISA bridging format; recorded at the EBF 10th Open Meeting (Barcelona, November 2017).

Michael Schwenkert talks about challenges associated with the development of CAR-T cell therapies that can be addressed using anti-idiotypic antibodies, and explains how Bio-Rad generates custom antibodies for this application (Barcelona, November 2018).

Ulrich Mayer describes how bioanalytical scientists can address the challenges of robust, selective and sensitive PK and ADA assay development through the use of customized anti-biotherapeutic antibodies generated by Bio-Rad (Barcelona, November 2019).


Articles

Monitoring antibody immune responses against biotherapeutic drugs

Monitoring antibody immune responses against biotherapeutic drugs

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Effective tools for drug monitoring assays

Effective tools for drug monitoring assays

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An accelerated approach to sensitive ADA assays

An accelerated approach to sensitive ADA assays

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Generation and Characterization of Drug-Target Complex-Specific Antibodies

Generation and characterization of drug-target complex-specific antibodies

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Posters

Faster generation of anti-drug antibodies using SpyTag technology

Faster generation of anti-drug antibodies using SpyTag technology
 

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Anti-Biotherapeutic Antibody Development against Ipilimumabwith HuCAL PLATINUM®

Anti-biotherapeutic antibody development against Ipilimumab with HuCAL PLATINUM®

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Drug-Target-Complex Specific Antibodies for Pharmacokinetic Analysis of Biotherapeutics

Drug-target-complex specific antibodies for pharmacokinetic analysis of biotherapeutics

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Characterization of anti-idiotypic antibodies for high performance in bioanalytical assays

Characterization of anti-idiotypic antibodies for high performance in bioanalytical assays

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Recombinant anti-idiotypic antibodies for antibody drug development

Recombinant anti-idiotypic antibodies for antibody drug development
 

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Fully human controls and reference standards

Webinar                            Article


Human recombinant antibodies as positive controls and calibrators

Human recombinant antibodies as positive controls and calibrators

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Recombinant antibodies as standards for immunodiagnostic assays

Recombinant antibodies as standards for immunodiagnostic assays

Learn More


Guided selection strategies for high specificity

Webinar

How to overcome assay challenges using custom recombinant antibodies

How to overcome assay challenges using custom recombinant antibodies

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Articles                                                                      

Generation of Antibodies Against Self-Antigens Using HuCAL Technology

Generation of antibodies against self-antigens using HuCAL technology
 

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Isolation of enzyme active site-specific recombinant antibodies by guided selection

Isolation of enzyme active site-specific recombinant antibodies by guided selection

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Biomarker assay development using highly specific antibodies

Biomarker assay development using highly specific antibodies

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Posters

Generation of recombinant anti-EGF R and anti-EGF R pTyr1045 antibodies

Generation of recombinant anti-EGF R and anti-EGF R pTyr1045 antibodies
 

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Generation of high affinity recombinant anti-IL-6 antibodies for application in Bio-Plex® assays

Generation of high affinity recombinant anti-IL-6 antibodies for application in Bio-Plex® assays

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Immuno-MRM

Webinar                            Article

Generation of high affinity recombinant antibodies for application in immuno-MRM

Generation of high affinity recombinant antibodies for application in immuno-MRM

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High-affinity antibodies for peptide pnrichment immuno-MRM

High-affinity antibodies for peptide enrichment immuno-MRM

Learn More