Neurodegeneration and Neurological Disease

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Neuroinflammation and the role of TLRs mini-review

Overview

Neurodegenerative disease has become one of the most exciting and well researched areas of neuroscience in the past few years.

This is due to the growing awareness of dementia within our society which is largely caused by diseases like Alzheimer’s. Neurodegeneration is basically the progressive loss of neurons via apoptosis, structural abnormalities, or a general failure to function.

We offer antibodies for researching a range of neurodegenerative diseases, including the following:

• Alzheimer’s Disease Antibodies
• Huntington’s Disease Antibodies
• Parkinson’s Disease Antibodies
• Amyotrophic Lateral Sclerosis Antibodies

At Bio-Rad we have made neurodegenerative diseases a key focus area, with reagents that include a panel of antibodies to the Huntingtin protein and antibodies to amyloid beta 1-42  for staining amyloid plaques in Alzheimer’s Disease brains.

View More on Apoptosis Research

Alzheimer’s Disease Antibodies

Alzheimer’s disease (AD) is one of the more prevalent neurodegenerative diseases, causing dementia in over 12 million people worldwide. Impairment in glutamate signaling through abnormal processing of amyloid precursor protein (APP) and the hyperphosphorylation of tau proteins (resulting in neurofibrillary tangles) are two possible causes of Alzheimer’s disease.

Amyotrophic Lateral Sclerosis (ALS) Antibodies

ALS, or Lou Gehring’s Disease, is a progressive and fatal form of motor neurone disease. Very few cases of the disease are thought to have hereditary cause, with the majority being sporadic. Although oxidative stress has been blamed for the onset of this disease, no definitive cause has been established.

Research in ALS often includes some of these specificities:

Huntington’s Disease Antibodies

Huntington’s disease (HD) is a trinucleotide repeat disease, which commonly has a genetic cause. A mutation in the Huntington gene (htt) is believed to be responsible for the onset of Huntington’s. This gene encodes the Huntingtin Protein, which is located in neurons throughout the brain.

Below are some key specificities for HD research, or search our entire product list by clicking here:

Parkinson’s Disease Antibodies

Parkinson’s disease (PD) affects approximately 7-10 million people worldwide, with statistically more men suffering from this progressive neurodegenerative disease than women.

Below are popular products for researching mechanisms and progression of PD:

Further reading:

1. Uchihara T. et al. (1996). Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer’s disease brains: double labelling immunohistochemical study. Acta. Neuropathol. 92, 325-330.