Neuroscience: Development and Repair Antibodies

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Overview

Development of the nervous system occurs via cellular and molecular mechanisms arising during embryogenesis. Neurogenesis encompasses the differentiation of neural stem cells (NSC) first into neurons, and later into axonal outgrowth via growth cones that respond to guidance cues, such as Ephrins, Semaphorins, Plexins, Neuropilins, and Netrins.

Antibodies for Studying Axonal Growth

The extraordinary level of accuracy during axonal outgrowth is of huge interest to researchers. Our key growth cone marker (MCA1712, clone 2G13) is ideal for studying axonal growth. The target recognized by this antibody, 2G13P, is localized to growth cones, particularly filopodia and lamellipodies in developing rat CNS and embryonic neurons in culture.

Studies suggest that the protein detected interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility. Additional key axonal growth antibodies are also available.

Further reading:

1. Stettler O et al. (1999). Monoclonal antibody 2G13, a new axonal growth cone marker.
   J. Neurocytol. 28, 1035 - 1044.